Slow Skeletal Troponin T (TNNT1) (Middle Region) Peptide
TNNT1
适用: 人
宿主: 合成
BP, WB
Quick Overview for Slow Skeletal Troponin T (TNNT1) (Middle Region) Peptide (ABIN985344)
抗原
TNNT1
(Slow Skeletal Troponin T (TNNT1))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- Middle Region
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产品特性
- This is a synthetic peptide designed for use in combination with anti-TNNT1 antibody (Catalog #: ARP42120_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TNNT1 (Slow Skeletal Troponin T (TNNT1))
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背景
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TNNT1 is a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year.This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: ANM, MGC104241, TNT, STNT, TNTS
Protein Interaction Partner: BMPR1B,CCDC85B,FXR2,NINL,PLEKHF1,PNMA1,PPFIA1,PRKG1,PSMC5,SMAD1,SMAD2,SMURF1,TGFBR1,TNNC1,TNNI1,TNNI2,TNNI3,TNNT1,TPM1,ZMYND19,CCDC85B,FXR2,NINL,PLEKHF1,PPFIA1,PRKG1,PSMC5,TNNC1,TNNT1,TPM1,ZMYND19
Protein Size: 278 -
分子量
- 33 kDa
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基因ID
- 7138
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NCBI登录号
- NM_003283, NP_003274
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UniProt
- P13805
抗原
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