Signal Transducer and Activator of Transcription 5B (STAT5B) (N-Term) Peptide
STAT5B
适用: 人
宿主: 合成
BP, IHC, WB
Quick Overview for Signal Transducer and Activator of Transcription 5B (STAT5B) (N-Term) Peptide (ABIN984535)
抗原
STAT5B
(Signal Transducer and Activator of Transcription 5B (STAT5B))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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蛋白结构域
- N-Term
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产品特性
- This is a synthetic peptide designed for use in combination with anti-STAT5B antibody (Catalog #: ARP39000_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))
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背景
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The protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: STAT5
Protein Interaction Partner: NMI,STAT5B,CBL,CD247,CENPJ,CRK,CRKL,CTLA4,CXCR4,EGFR,ELP2,EP300,EPOR,ERBB4,ETS1,ETS2,GHR,IL2RA,IL2RB,IL7R,INSR,JAK2,KIT,MAPK1,NCOR2,NMI,NR3C1,PDGFRA,PDGFRB,POU2F1,PPP2CA,PTPN1,PTPN11,PTPN2,PTPN6,RARA,SHC1,SRC,STAP2,STAT1,STAT3,STAT5A,STAT5B,TEK,CCR5,CD247,EGFR,ELP2,GHR,IL2RB,JAK1,JAK2,JAK3,NMI,NR3C1,PTPN1,PTPN11,PTPN6,SHC1
Protein Size: 787 -
分子量
- 90 kDa
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基因ID
- 6777
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NCBI登录号
- NM_012448, NP_036580
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UniProt
- P51692
抗原
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