Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (N-Term) Peptide
STAT3
适用: 人
宿主: 合成
BP, WB, IF, IHC
产品编号 ABIN984529
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (N-Term) Peptide (ABIN984529)
抗原
STAT3
(Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
-
-
蛋白结构域
- N-Term
-
产品特性
- This is a synthetic peptide designed for use in combination with anti-STAT3 antibody (Catalog #: ARP38253_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
纯化方法
- Purified
-
-
Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) peptide
STAT3 适用: 人, 小鼠, 大鼠, 犬 宿主: 合成 BP, Imm
-
-
应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
浓度
- 1 mg/mL
-
缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
-
注意事项
- Avoid repeated freeze-thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
-
背景
-
STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. It mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Alias Symbols: APRF, FLJ20882, MGC16063, HIES
Protein Interaction Partner: NMI,BHLHE40,CREBBP,EGFR,EP300,HDAC1,HDAC2,HDAC3,NMI,PRKCB,PRKCD,STAT3,BHLHE40,AR,BHLHE40,BMX,BRCA1,CCND1,CCR1,CCR5,CDKN1A,CREBBP,CSF2RB,CSF3R,CXCR4,DAXX,EGFR,EIF2AK2,ELP2,EP300,EPHA3,FER,FES,FGFR3,FGFR4,FOXM1,GATA1,GATA2,GHR,GNB2L1,GTF2I,HCK,HDAC1,HDAC2,HDAC3,HES1,HES5,HIF1A,HNF1A,HSP90AA1,HSP90AB1,IFNAR1,IFNAR2,IGF1R,IL1RAP,IL23R,IL2RA,IL2RB,IL6R,IL6ST,IL7R,IRAK1,JAK1,JAK2,JAK3,JUN,KAT5,KHDRBS1,KPNA1,KPNA6,LCK,LEPR,MAP3K7,MAPK1,MAPK3,MAPK8,MET,MTOR,MYOD1,NCOA1,NDUFA13,NFKB1,NLK,NMI,NR3C1,PDGFRA,PDGFRB,PDIA3,PIAS3,PML,PRKCD,PTK2B,PTMA,PTPN11,PTPN2,RAC1,RELA,RET,RPA2,RPS6KA5,SRC,STAP2,STAT1,STAT3,STAT4,STAT5A,STAT5B,STMN1,SUMO4,SYK,TSHR,TSLP,ZNF148,ZNF467,A2M,ALK,AR,BMX,CCND1,CCND1,CCR5,CDKN1A,CREBBP,CTR9,EGFR,EIF2AK2,ELP2,EP300,EPHA5,ERBB2,ESR1,FES,FOS,GHR,GTF2I,HIF1A,HNF1A,HSP90AA1,IFNAR1,IL1RAP,IL2RB,IL6R,IL6ST,IL6ST,JAK1,JAK2,JUN,KAT5,KHDRBS1,LEP,MET,MTOR,MYOD1,NCOA1,NDUFA13,NDUFA13,NFKB1,NMI,NR3C1,PDIA3,PIAS3,PML,PTK2,PTPN11,PTPN2,RAC1,RELA,RET,RPA2,SMAD1,SRC,STAT1,TRIP10,TSHR
Protein Size: 769 -
分子量
- 88 kDa
-
基因ID
- 6774
-
NCBI登录号
- NM_003150, NP_003141
-
UniProt
- B5BTZ6
抗原
-
You are here:
