Suppressor of Cytokine Signaling 7 (SOCS7) (N-Term) Peptide
SOCS7
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN984229
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Quick Overview for Suppressor of Cytokine Signaling 7 (SOCS7) (N-Term) Peptide (ABIN984229)
抗原
SOCS7
(Suppressor of Cytokine Signaling 7 (SOCS7))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- N-Term
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产品特性
- This is a synthetic peptide designed for use in combination with anti-SOCS7 antibody (Catalog #: ARP53700_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))
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背景
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SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Alias Symbols: NAP4, NCKAP4
Protein Interaction Partner: EGFR,GRB2,IRS2,IRS4,NCK1,PIK3R1,PIK3R2,PLCG1,SORBS3,TUBA1A,TUBB2C,NCK1
Protein Size: 581 -
分子量
- 64 kDa
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基因ID
- 30837
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NCBI登录号
- NM_014598, NP_055413
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UniProt
- O14512
抗原
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