This is a synthetic peptide designed for use in combination with anti-SMAD4 antibody (Catalog #: ARP32005_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Each Investigator should determine their own optimal working dilution for specific applications.
限制
仅限研究用
状态
Lyophilized
溶解方式
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
浓度
1 mg/mL
缓冲液
Final peptide concentration is 1 mg/mL in PBS.
注意事项
Avoid repeated freeze-thaw cycles.
储存条件
-20 °C
储存方法
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
抗原
SMAD4
(SMAD Family Member 4 (SMAD4))
别名
smad4 Peptide, DPC4 Peptide, JIP Peptide, MADH4 Peptide, MYHRS Peptide, AW743858 Peptide, D18Wsu70e Peptide, Madh4 Peptide, XSmad4alpha Peptide, Xsmad4 Peptide, dpc4 Peptide, jip Peptide, madh4 Peptide, xsmad4a Peptide, SMAD family member 4 Peptide, Smad4 protein Peptide, SMAD family member 4, gene 1 L homeolog Peptide, SMAD4 Peptide, smad4 Peptide, Smad4 Peptide, smad4.1.L Peptide
背景
SMAD4 is one of the Smad family members, which are essential intracellular signalling components of the transforming growth factor-beta (TGF-beta) superfamily. Smad2 and Smad3 are structurally highly similar and mediate TGF-beta signals. Smad4 is distantly related to Smads 2 and 3, and forms a heteromeric complex with Smad2 after TGF-beta or activin stimulation. TGF-beta induces heteromeric complexes of Smads 2, 3 and 4, and their concomitant translocation to the nucleus, which is required for efficient TGF-beta signal transduction
Alias Symbols: JIP, DPC4, MADH4, MYHRS
Protein Interaction Partner: BRCA1,CDKN1A,CEBPB,FOXO1,FOXO3,FOXO4,SKI,SKI,SKIL,SMAD1,SMAD2,SMAD2,SMAD3,SMAD3,STUB1,SUMO1,TGFB1I1,TGFBR1,TGFBR2,TRIM33,TSSK3,ACVR1B,AKT1,AP2B1,APBB2,AR,ARFRP1,ARL5B,ATF2,ATF7IP,BRCA1,BTRC,C16orf57,CAMK2G,CD59,CEBPB,CHEK1,CITED1,CNKSR1,COPS5,CREBBP,CSH1,CTCF,CTNNB1,DACH1,DCP1A,DCP1B,DLX1,DNAJB2,DVL1,ECSIT,EEF1A1,EID2,EIF2AK4,EP300,ERBB2IP,ESR1,ESR2,EWSR1,FBLN1,FBXO30,FBXO34,FN1,FOXG1,FOXH1,FOXO1,FOXO3,FOXO4,FSTL3,GLI3,GPNMB,HDGF,HDLBP,HMG20A,HNF4A,HOXA9,HOXC8,ITK,JUN,JUNB,JUND,LEF1,MAPK1,MAPK13,MAX,MEF2A,MEX3B,MYOD1,NAT8,NEK6,NOTCH4,NRAS,NUAK2,NUP214,OCLN,ODZ3,PAK1,PAPPA2,PARD3,PBK,PIAS1,PIAS2,PIAS3,PIAS4,PLK4,PRKAR1B,PRKAR2A,PRPF40A,PSG2,PSG9,PSMD11,RAB13,RAB25,RAB2B,RAB34,RAB38,RAB3B,RAC2,RALA,RASD2,RASL12,RBL1,RFX1,RHEBL1,RHOD,RHOG,RHOJ,RIPK2,RMND5B,RPL28,RPS27A,RRAS2,RTDR1,SASH3,SKI,SKIL,SMAD1,SMAD2,SMAD3,SMAD4,SMAD5,SMAD9,SNIP1,SNRNP70,SP1,SPTBN1,SQSTM1,STK11IP,STK35,STUB1,TCTA,TDG,TFE3,TGFBR1,TGFBR2,TGFBRAP1,TH1L,TM9SF2,TOB1,TRAP1,TSSK3,UBA52,UBB,UBE2I,UBE2L3,UBE2Z,UHRF2,XPO5,ZBED5,ZMYM2,ZNF423,ZNF521,ZNF8,AKT1,AR,ATF2,Ap2b1,Apbb2,Arfrp1,Arhgef11,Arhgef7,Arl5b,BTRC,CAMK2G,CEBPA,CEBPB,CEBPD,CITED1,COPS5,CTNNB1,Chek1,DCP1A,DLX1,DVL1,EID2,EP300,EP300,ERBB2IP,EWSR1,Eif2ak4,FOXH1,FOXO1,FOXO3,FOXO4,HOXA9,HOXC8,Hdgf,Ilkap,Itk,JUNB,KPNB1,LEF1,MAX,MDM4,Map2k3,Nek6,Nras,Nuak2,Ocln,PARD3B,PIAS3,PIAS4,Pbk,Plk4,RBL1,Rab13,Rab2b,Rab34,Rab38,Rab3b,Rac2,Rasd2,Rhod,Rhog,Rhoj,Ripk2,Rnf138,Rnf14,Rps27a,Rras2,Rtdr1,SKI,SKIL,SMAD1,SMAD2,SMAD3,SMAD5,SMAD6,SMAD7,SMAD9,SNIP1,SNW1,STK11IP,Smad1,Smad2,Smad3,Sqstm1,Stat1,Stk35,TFE3,TGFBR1,TGFBRAP1,TOB1,Trim35,Tssk3,UBE2I,Ubb,Uhmk1,ZNF423,Zfp128