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Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (Middle Region) Peptide

SIGLEC10 适用: 人 宿主: 合成 BP, WB
产品编号 ABIN983734
发货至: 中国
  • 抗原 See all SIGLEC10 products
    SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))
    蛋白结构域
    Middle Region
    宿主
    资源
    • 2
    合成
    应用范围
    Blocking Peptide (BP), Western Blotting (WB)
    产品特性
    This is a synthetic peptide designed for use in combination with anti-SIGLEC10 antibody (Catalog #: ARP50160_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    纯化方法
    Purified
  • 应用备注
    Each Investigator should determine their own optimal working dilution for specific applications.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    浓度
    1 mg/mL
    缓冲液
    Final peptide concentration is 1 mg/mL in PBS.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • 抗原
    SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))
    背景
    SIGLEC10 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. SIGLEC10 preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, SIGLEC10 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-653 AC008750.9 90495-91147 c 654-760 DA387605.1 391-497 761-2959 AF301007.1 262-2460 2960-3794 AY358337.1 1930-2764

    Alias Symbols: MGC126774, PRO940, SIGLEC-10, SLG2

    Protein Interaction Partner: FLNA,PTPN6

    Protein Size: 697
    分子量
    76 kDa
    基因ID
    89790
    NCBI登录号
    NM_033130, NP_149121
    UniProt
    Q96LC7
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