E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) Peptide
SIAH1
适用: 人
宿主: 合成
BP, IHC, WB
产品编号 ABIN983729
发货至:
中国
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Contact Info
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中国
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北京 101111
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Quick Overview for E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) Peptide (ABIN983729)
抗原
SIAH1
(E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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产品特性
- This is a synthetic peptide designed for use in combination with anti-SIAH1 antibody (Catalog #: ARP38212_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) peptide
SIAH1 适用: 人, 大鼠, Cow, 犬, 小鼠 宿主: 合成 BP, Imm
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SIAH1 (E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1))
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背景
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SIAH1 is a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterizedThis gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Alias Symbols: SIAH1A
Protein Interaction Partner: DCC,DCC,UBE2I,UBE2I,AFF1,AFF4,APC,ATN1,BAG1,CACYBP,DAB1,DCC,EIF3J,GAPDH,HIPK3,KHDRBS3,KIF22,NUMB,PEG10,PEG3,PKD1,POU2AF1,RBBP8,SH3RF1,SIAH1,SLC9A3R2,SNCAIP,SYP,TUBA1A,TUBA1B,TUBA3C,TUBA4A,TUBA8,UBE2D1,AFF4,APC,BAG1,CACYBP,DAB1,DCC,HIF1AN,KHDRBS3,KIF22,NUMB,PEG10,PEG3,PIAS1,PIAS2,PIAS3,POU2AF1,RBBP8,SIAH1,SYP,TBL1X,TRIB3,UBE2D1,UBE2E3,UBE2I,VAV1
Protein Size: 282 -
分子量
- 31 kDa
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基因ID
- 6477
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NCBI登录号
- NM_003031, NP_003022
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UniProt
- Q8IUQ4
抗原
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