SH3 Domain Containing Ring Finger 1 (SH3RF1) (Middle Region) Peptide
SH3RF1
适用: 人
宿主: 合成
BP, WB
-
- 抗原 See all SH3RF1 products
- SH3RF1 (SH3 Domain Containing Ring Finger 1 (SH3RF1))
- 蛋白结构域
- Middle Region
- 宿主
- 人
-
资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-SH3RF1 antibody (Catalog #: ARP43283_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
-
-
- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- 抗原
- SH3RF1 (SH3 Domain Containing Ring Finger 1 (SH3RF1))
- 背景
-
SH3RF1 acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9). SH3RF1 may be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane.This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.
Alias Symbols: FLJ21602, KIAA1494, POSH, RNF142, SH3MD2
Protein Interaction Partner: ADAM15,AKT2,MAP3K10,MAP3K11,MAP3K12,MAP3K9,PAK2,RACGAP1,SEMA6A,SIAH1,AKT2,MAP3K11
Protein Size: 888 - 分子量
- 93 kDa
- 基因ID
- 57630
- NCBI登录号
- NM_020870, NP_065921
- UniProt
- Q7Z6J0
-
You are here:
