Runt-Related Transcription Factor 2 (RUNX2) (N-Term) Peptide
RUNX2
适用: 人
宿主: 合成
BP, WB
Quick Overview for Runt-Related Transcription Factor 2 (RUNX2) (N-Term) Peptide (ABIN983332)
抗原
RUNX2
(Runt-Related Transcription Factor 2 (RUNX2))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- N-Term
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序列
- MRIPVDPSTS RRFSPPSSSL QPGKMSDVSP VVAAQQQQQQ QQQQQQQQQQ
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产品特性
- This is a synthetic peptide designed for use in combination with anti-RUNX2 Antibody(ARP38452_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))
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背景
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RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis, acting as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants, encoding different protein isoforms, result from alternate promoter use as well as alternate splicing.
Alias Symbols: AML3, CBFA1, CCD, CCD1, MGC120022, MGC120023, OSF2, PEA2aA, PEBP2A1, PEBP2A2, PEBP2aA, PEBP2aA1, OSF-2
Protein Interaction Partner: RB1,AR,AXIN1,CBFB,CCNB1,CDK1,CEBPB,DVL2,EP300,ETS1,FOS,HDAC3,HDAC4,HDAC6,JUN,LEF1,MAP3K4,MSX2,MYST4,PRKCD,RB1,SMAD2,SMAD3,SMAD6,TAF1A,UBTF,XRCC5,XRCC6,YAP1,BMPR1A,EP300,ETS1,FOS,HDAC1,HDAC3,HDAC4,HDAC5,HDAC6,HES1,JUN,KAT2B,LEF1,MSX2,MYST4,SMAD1,SMAD2,SMAD
Protein Size: 507 -
分子量
- 55 kDa
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基因ID
- 860
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NCBI登录号
- NM_004348, NP_004339
抗原
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