Ring Finger Protein 11-Like (RNF11L) (C-Term) Peptide
RNF11L
适用: 人, 大鼠
宿主: 合成
BP, WB
Quick Overview for Ring Finger Protein 11-Like (RNF11L) (C-Term) Peptide (ABIN983037)
抗原
RNF11L
(Ring Finger Protein 11-Like (RNF11L))
宿主
人, 大鼠
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
-
-
蛋白结构域
- C-Term
-
序列
- GLIQHLPKGG YDPGRDGSEK KIRECVICMM DFVYGDPIRF LPCMHIYHLD
-
产品特性
- This is a synthetic peptide designed for use in combination with anti-Rnf11l Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
纯化方法
- Purified
-
-
-
应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
浓度
- 1 mg/mL
-
缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
-
注意事项
- Avoid repeated freeze-thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- RNF11L (Ring Finger Protein 11-Like (RNF11L))
-
背景
-
Rnf11l is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Rnf11l promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Rnf11l recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
Alias Symbols: Rnf11
Protein Size: 280 -
分子量
- 30 kDa
-
基因ID
- 316552
-
NCBI登录号
- XM_237327, XP_237327
抗原
-
You are here:
