RE1-Silencing Transcription Factor (REST) (Middle Region) Peptide
REST
适用: 小鼠
宿主: 合成
BP, WB
产品编号 ABIN982857
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Quick Overview for RE1-Silencing Transcription Factor (REST) (Middle Region) Peptide (ABIN982857)
抗原
REST
(RE1-Silencing Transcription Factor (REST))
宿主
小鼠
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- Middle Region
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序列
- ANMGMALTND MYDLHELSKA ELAAPQLIML ANVALTGEAS GSCCDYLVGE
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产品特性
- This is a synthetic peptide designed for use in combination with anti-Rest Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- REST (RE1-Silencing Transcription Factor (REST))
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背景
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Rest is a transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Rest restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Rest mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
Alias Symbols: 2610008J04Rik, AA407358, MGC150099, NRSF
Protein Size: 1082 -
分子量
- 118 kDa
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基因ID
- 19712
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NCBI登录号
- NM_011263, NP_035393
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UniProt
- Q8VIG1
抗原
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