Nuclear Factor-kB p65 (NFkBP65) (Middle Region) Peptide
NFkBP65
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN982836
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Quick Overview for Nuclear Factor-kB p65 (NFkBP65) (Middle Region) Peptide (ABIN982836)
抗原
NF-kB p65 (NFkBP65)
(Nuclear Factor-kB p65 (NFkBP65))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- Middle Region
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产品特性
- This is a synthetic peptide designed for use in combination with anti-RELA antibody (Catalog #: ARP30305_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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Nuclear Factor-kB p65 (NFkBP65) peptide
NFkBP65 宿主: 合成 Sodium azide
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- NF-kB p65 (NFkBP65) (Nuclear Factor-kB p65 (NFkBP65))
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背景
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P65 is a subunit of the nuclear factor kappa-B, a second messenger, which activates the transcription of a number of genes in multiple tissues. The inhibitory effect of I-kappa-B upon NF-kappa-B in the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1760 M62399.1 8-1767
Alias Symbols: MGC131774, NFKB3, p65
Protein Interaction Partner: AES,BIRC3,CARM1,CCND1,CHEK1,CHUK,CREBBP,CREBBP,CXCL10,EGR1,EP300,EP300,FOS,IL8,ING4,JUN,NCOA3,NFKB1,NFKB1,NFKBIA,NFKBIA,NFKBIB,NFKBIB,SLC1A2,TERT,TLE1,AATF,ACTL6A,AES,AHR,AKAP8,APBA2,AR,BRCA1,BTK,BTRC,CALM1,CAMK4,CARM1,CDK9,CEBPB,CEBPD,CHEK1,CHUK,COMMD1,CREBBP,CSNK2A1,DDX1,DHX9,EGR1,EP300,ESR1,ETHE1,FAF1,FOS,FUS,GTF2B,HDAC1,HDAC2,HDAC3,HEXIM1,HMGA2,HMGB1,IKBKB,ING4,IRAK1BP1,IRF1,IRF2,IRF3,JUN,KAT2B,KPNA2,MAP2K6,MAP3K7,MAP3K8,MEN1,MST1R,MTPN,MYC,NCOA3,NCOR2,NFKB1,NFKB2,NFKBIA,NFKBIB,NFKBIE,NKRF,NKX2-1,NOTCH1,NR3C1,PARP1,PDCD11,PGR,PIAS1,PIAS3,PIN1,PML,POU2F1,PPARA,PPP1R13L,PPP2CA,PPP2R1B,PPP4C,PRKACA,PRKCZ,PRTN3,REL,RELA,RELB,REPS2,RFC1,RNF25,RPS6KA5,RXRA,SIRT1,SNIP1,SOCS1,SP1,SRF,STAT1,STAT3,STAT6,TAF1,TAF11,TAF4B,TAF6,TBK1,TBP,TERT,TNIP2,TP53BP1,TP53BP2,TRIB3,TRIP4,TSC22D3,TWIST1,UNC5CL,AES,AHR,AKAP8L,APBA2,ASCC1,ASCC2,ASCC3,BARD1,BRCA1,BTRC,CDK9,CEBPB,CEBPD,COMMD1,CREBBP,CSNK2A1,CSNK2A2,DHX9,EGR1,EP300,ETHE1,FOS,FUS,GTF2B,HDAC1,HDAC2,HDAC3,HEXIM1,HMGA2,HMGB1,Hdac1,ING4,IQGAP2,IRF2,IRF8,IRF9,ITGB3BP,JUN,KDM2A,KPNA2,MAP3K8,MEN1,MTPN,MYC,NCF1,NCOA6,NCOR2,NFKB1,NFKB2,NFKBIA,NFKBIB,NFKBIE,NKRF,NKX2-1,NOTCH1,NR3C1,NSD1,PARP1,PDLIM2,PGR,PIAS3,PML,POU2F1,PPARA,PPP1R13L,PPP2CA,PPP2CB,PPP4C,PRKCZ,REL,RELA,RELB,RFC1,RNF25,RXRA,SOCS1,SP1,SRF,STAT3,TAF1,TAF11,TAF4B,TAF6,TBK1,TBP,TERT,TLE1,TNIP2,TRIB3,TWIST1,UBC,UNC5CL
Protein Size: 551 -
分子量
- 60 kDa
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基因ID
- 5970
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NCBI登录号
- NM_021975, NP_068810
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UniProt
- Q04206
抗原
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