Perforin 1 (Pore Forming Protein) (PRF1) Peptide
PRF1
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN982195
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Perforin 1 (Pore Forming Protein) (PRF1) Peptide (ABIN982195)
抗原
Perforin 1 (PRF1)
(Perforin 1 (Pore Forming Protein) (PRF1))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
-
-
产品特性
- This is a synthetic peptide designed for use in combination with anti-PRF1 antibody (Catalog #: ARP42208_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
纯化方法
- Purified
-
-
-
-
应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
浓度
- 1 mg/mL
-
缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
-
注意事项
- Avoid repeated freeze-thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
-
背景
-
PRF1 has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in the gene encoding PRF1 cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.
Alias Symbols: FLH2, HPLH2, MGC65093, P1, PFP, PFN1
Protein Interaction Partner: CALR,DDX24,GZMB,CALR
Protein Size: 555 -
分子量
- 59 kDa
-
基因ID
- 5551
-
NCBI登录号
- NM_005041, NP_005032
-
UniProt
- P14222
抗原
-
You are here:
