Perforin 1 (Pore Forming Protein) (PRF1) Peptide
PRF1
适用: 人
宿主: 合成
BP, WB
Quick Overview for Perforin 1 (Pore Forming Protein) (PRF1) Peptide (ABIN982195)
抗原
Perforin 1 (PRF1)
(Perforin 1 (Pore Forming Protein) (PRF1))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
-
-
产品特性
- This is a synthetic peptide designed for use in combination with anti-PRF1 antibody (Catalog #: ARP42208_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
纯化方法
- Purified
-
-
-
-
应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
浓度
- 1 mg/mL
-
缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
-
注意事项
- Avoid repeated freeze-thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
-
背景
-
PRF1 has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in the gene encoding PRF1 cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.
Alias Symbols: FLH2, HPLH2, MGC65093, P1, PFP, PFN1
Protein Interaction Partner: CALR,DDX24,GZMB,CALR
Protein Size: 555 -
分子量
- 59 kDa
-
基因ID
- 5551
-
NCBI登录号
- NM_005041, NP_005032
-
UniProt
- P14222
抗原
-
You are here:
