Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) (Middle Region) Peptide
POLR3C
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN981969
发货至:
中国
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Contact Info
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Quick Overview for Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) (Middle Region) Peptide (ABIN981969)
抗原
POLR3C
(Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- Middle Region
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序列
- VEAIIASMQA TGAEEAQLQE IEEMITAPER QQLETLKRNV NKLDASEIQV
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产品特性
- This is a synthetic peptide designed for use in combination with anti-POLR3C Antibody(ARP52190_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))
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背景
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DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3C is a specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. POLR3C may direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. POLR3C may be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. POLR3C plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.POLR3C acts as nuclear and cytosolic DNA sensor involved in innate immune response. POLR3C can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
Alias Symbols: RPC3, RPC62
Protein Interaction Partner: GTF3C4,GTF3C1,GTF3C2,GTF3C3,GTF3C4,GTF3C5,POLR3D,POLR3F,POLR3G,POLR3H,TBP
Protein Size: 534 -
分子量
- 60 kDa
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基因ID
- 10623
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NCBI登录号
- NM_006468, NP_006459
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UniProt
- Q9BUI4
抗原
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