Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2) (Middle Region) Peptide
PLOD2
适用: 人
宿主: 合成
BP, WB, IHC
Quick Overview for Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2) (Middle Region) Peptide (ABIN981868)
抗原
PLOD2
(Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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蛋白结构域
- Middle Region
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产品特性
- This is a synthetic peptide designed for use in combination with anti-PLOD2 antibody (Catalog #: ARP42731_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PLOD2 (Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2))
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背景
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PLOD2 forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: LH2, TLH
Protein Interaction Partner: PLOD2,HNRNPA1,PLOD2,RUVBL2
Protein Size: 758 -
分子量
- 84 kDa
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基因ID
- 5352
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NCBI登录号
- NM_182943, NP_891988
抗原
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