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Protein Inhibitor of Activated STAT, 2 (PIAS2) Peptide

PIAS2 适用: 人 宿主: 合成 BP, WB, IHC
产品编号 ABIN981729
发货至: 中国
  • 抗原 See all PIAS2 products
    PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
    宿主
    资源
    • 11
    合成
    应用范围
    Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
    产品特性
    This is a synthetic peptide designed for use in combination with anti-Pias2 antibody (Catalog #: ARP36929_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    纯化方法
    Purified
  • 应用备注
    Each Investigator should determine their own optimal working dilution for specific applications.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    浓度
    1 mg/mL
    缓冲液
    Final peptide concentration is 1 mg/mL in PBS.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • 抗原
    PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
    别名
    MGC83751 Peptide, piasx Peptide, wu:fi05f09 Peptide, PIAS2 Peptide, 6330408K17Rik Peptide, AI462206 Peptide, ARIP3 Peptide, AU018068 Peptide, Dib Peptide, Miz1 Peptide, PIASxalpha Peptide, PIASxb Peptide, PIASxbeta Peptide, SIZ2 Peptide, DIP Peptide, MIZ Peptide, MIZ1 Peptide, PIASX Peptide, PIASX-ALPHA Peptide, PIASX-BETA Peptide, ZMIZ4 Peptide, protein inhibitor of activated STAT 2 L homeolog Peptide, protein inhibitor of activated STAT 2 Peptide, protein inhibitor of activated STAT, 2 Peptide, pias2.L Peptide, PIAS2 Peptide, pias2 Peptide, Pias2 Peptide
    背景
    Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It seems to be mostly involved in gene silencing. It binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity.

    Alias Symbols: 6330408K17Rik, AI462206, ARIP3, AU018068, Dib, Miz1, PIASxalpha, PIASxb, PIASxbeta, SIZ2

    Protein Interaction Partner: Gtf2i,Hdac3,GTF2I,GTF2IRD1,HDAC3

    Protein Size: 490
    分子量
    54 kDa
    基因ID
    17344
    NCBI登录号
    NM_001164167
    UniProt
    Q8C5D8
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