Poly(rC) Binding Protein 1 (PCBP1) (Middle Region) Peptide
PCBP1
适用: 人
宿主: 合成
BP, WB, IHC
Quick Overview for Poly(rC) Binding Protein 1 (PCBP1) (Middle Region) Peptide (ABIN981427)
抗原
PCBP1
(Poly(rC) Binding Protein 1 (PCBP1))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
-
-
蛋白结构域
- Middle Region
-
序列
- PHATHDLEGP PLDAYSIQGQ HTISPLDLAK LNQVARQQSH FAMMHGGTGF
-
产品特性
- This is a synthetic peptide designed for use in combination with anti-PCBP1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
纯化方法
- Purified
-
-
-
-
应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
浓度
- 1 mg/mL
-
缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
-
注意事项
- Avoid repeated freeze-thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))
-
背景
-
PCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. PCBP1 is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.This intronless gene is thought to be generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
Alias Symbols: HNRPE1, HNRPX, hnRNP-E1, hnRNP-X
Protein Size: 356 -
分子量
- 37 kDa
-
基因ID
- 5093
-
NCBI登录号
- NM_006196, NP_006187
-
UniProt
- Q15365
抗原
-
You are here:
