Purine Nucleoside Phosphorylase (PNP) (Middle Region) Peptide
PNP
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN980823
发货至:
中国
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Contact Info
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中国
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Quick Overview for Purine Nucleoside Phosphorylase (PNP) (Middle Region) Peptide (ABIN980823)
抗原
PNP
(Purine Nucleoside Phosphorylase (PNP))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- Middle Region
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产品特性
- This is a synthetic peptide designed for use in combination with anti-NP antibody (Catalog #: ARP48474_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PNP (Purine Nucleoside Phosphorylase (PNP))
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物质类
- Viral Protein
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背景
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Defects in NP are the cause of nucleoside phosphorylase deficiency (NP deficiency). It leads to a severe T-cell immunodeficiency with neurologic disorder in children. The specific function of NP is not yet known.This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC117396, MGC125915, MGC125916, PNP, PRO1837, PUNP, NP
Protein Interaction Partner: APLP1,C1orf103,C7orf64,CCDC90B,NCALD,TFAM,TFB2M,TP53,ZHX1,APLP1,C1orf103,C7orf64,CCDC90B,TP53,ZHX1
Protein Size: 289 -
分子量
- 32 kDa
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基因ID
- 4860
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NCBI登录号
- NM_000270, NP_000261
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UniProt
- P00491
抗原
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