Noggin (NOG) (Middle Region) Peptide
NOG
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all NOG products
- NOG (Noggin (NOG))
- 蛋白结构域
- Middle Region
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- GGHYDPGFMA TSPPEDRPGG GGGAAGGAED LAELDQLLRQ RPSGAMPSEI
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-NOG Antibody(ARP58773_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- NOG (Noggin (NOG))
- 别名
- SYM1 Peptide, SYNS1 Peptide, nog-A Peptide, nog1 Peptide, noggin-1 Peptide, noggin Peptide, noggin Peptide, noggin L homeolog Peptide, noggin protein Peptide, NOG Peptide, Nog Peptide, nog.L Peptide, noggin Peptide
- 背景
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The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified, both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse.
Alias Symbols: SYM1, SYNS1
Protein Interaction Partner: BMP2,BMP4,BMP5,BMP7,BMP7,NOG
Protein Size: 232 - 分子量
- 24 kDa
- 基因ID
- 9241
- NCBI登录号
- NM_005450, NP_005441
- UniProt
- Q13253
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