Microphthalmia-Associated Transcription Factor (MITF) (Middle Region) Peptide
MITF
适用: 人
宿主: 合成
BP, WB
Quick Overview for Microphthalmia-Associated Transcription Factor (MITF) (Middle Region) Peptide (ABIN980098)
抗原
MITF
(Microphthalmia-Associated Transcription Factor (MITF))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- Middle Region
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产品特性
- This is a synthetic peptide designed for use in combination with anti-MITF antibody (Catalog #: ARP37978_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MITF (Microphthalmia-Associated Transcription Factor (MITF))
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背景
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MITF is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: WS2A, MI, WS2, bHLHe32
Protein Interaction Partner: CTNNB1,EP300,FOS,GSK3B,LEF1,MAPK1,MAPK14,OTX2,PATZ1,PAX3,PAX6,PIAS3,RPS6KA1,SPI1,SUMO1,TFE3,TFEB,TFEC,UBE2I,CDK2,CDKN1A,FOS,LEF1,PATZ1,PAX6,PIAS3,RB1,SPI1,TFE3,TFEC,UBE2I
Protein Size: 419 -
分子量
- 47 kDa
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基因ID
- 4286
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NCBI登录号
- NM_000248, NP_000239
抗原
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