This is a synthetic peptide designed for use in combination with anti-MGMT Antibody(ARP42038_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
MGMT is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA.MGMT repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Alias Symbols: -
Protein Interaction Partner: CREBBP,CSNK2A1,EP300,PRKACA,PRKCA,UBA1,HIST4H4,ACTB,ANP32E,ANXA1,ANXA2,CCNB1,CDK1,CDK10,CDK12,CDK2,CDKL5,CDKN1A,CREBBP,CSNK2A1,CSNK2A2,DDX24,DDX5,EEF1A1,EEF1A2,EEF1B2,EIF3H,EP300,ESR1,FBL,FBXO2,FBXO27,H2BFM,HIST1H2AM,HIST1H4A,HIST3H3,HNRNPA2B1,HNRNPC,HSP9