Mdc1 (MDC1) (C-Term) Peptide
MDC1
适用: 人
宿主: 合成
BP, WB
Quick Overview for Mdc1 (MDC1) (C-Term) Peptide (ABIN979918)
抗原
MDC1
(Mdc1 (MDC1))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- C-Term
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序列
- GKEEDVVTPK PGKRKRDQAE EEPNRIPSRS LRRTKLNQES TAPKVLFTGV
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产品特性
- This is a synthetic peptide designed for use in combination with anti-MDC1 Antibody,. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MDC1 (Mdc1 (MDC1))
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背景
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The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Alias Symbols: DKFZp781A0122, KIAA0170, MGC166888, NFBD1
Protein Interaction Partner: ATM,BARD1,BRCA1,CHEK2,CREBBP,EP300,H2AFX,MDC1,NBN,SMC1A,TP53,TP53BP1,USP28,ATM,BANF1,BRCA1,CENPC1,CHEK2,GATA4,H2AFX,HDAC10,HDAC8,MCPH1,MDM2,MRE11A,NBN,POLR2A,RAD50,RAD51,SUMO2,TP53,TP53BP1,UBC,USP28,WRN
Protein Size: 2089 -
分子量
- 227 kDa
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基因ID
- 9656
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NCBI登录号
- NM_014641, NP_055456
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UniProt
- Q14676
抗原
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