Minichromosome Maintenance Complex Component 7 (MCM7) Peptide
MCM7
适用: 人
宿主: 合成
BP, WB, IHC
产品编号 ABIN979902
发货至:
中国
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Contact Info
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中国
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Quick Overview for Minichromosome Maintenance Complex Component 7 (MCM7) Peptide (ABIN979902)
抗原
MCM7
(Minichromosome Maintenance Complex Component 7 (MCM7))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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产品特性
- This is a synthetic peptide designed for use in combination with anti-MCM7 antibody (Catalog #: ARP36652_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MCM7 (Minichromosome Maintenance Complex Component 7 (MCM7))
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背景
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MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: MCM2, CDC47, P85MCM, P1CDC47, PNAS146, P1.1-MCM3
Protein Interaction Partner: RB1,RBL1,RBL2,MCM3,MCM4,MCM7,ATRIP,CCNH,CDC45,CDC6,CDC7,CDK7,CDKN1B,CRLS1,DBF4,FHL2,HIST3H3,MBIP,MCM10,MCM2,MCM3,MCM4,MCM5,MCM6,MCM7,MCM8,MNAT1,NFKBIA,ORC1L,ORC2L,ORC3L,ORC4L,ORC5L,ORC6L,PLK1,RAD17,RB1,RBL1,RBL2,RBM8A,RPA1,SMC1A,UBE3A,ATR,ATRIP,CCNH,CDC45,CDC6,CDC7,CDK7,CDT1,CNOT8,DBF4,FHL2,GIPC1,GSTK1,MBIP,MCM10,MCM2,MCM3,MCM3,MCM4,MCM4,MCM5,MCM6,MCM7,MCM8,MNAT1,MYC,NEK6,ORC1L,ORC2L,ORC3L,ORC5L,PELO,RB1,RBL1,RBL2,RBM8A,RECQL5,RPA1,TH1L,TRAF6,UBE3A
Protein Size: 719 -
分子量
- 81 kDa
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基因ID
- 4176
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NCBI登录号
- NM_005916, NP_005907
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UniProt
- P33993
抗原
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