Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (C-Term) Peptide
MANF
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN979757
发货至:
中国
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Contact Info
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Quick Overview for Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (C-Term) Peptide (ABIN979757)
抗原
MANF
(Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- C-Term
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序列
- EKICEKLKKK DSQICELKYD KQIDLSTVDL KKLRVKELKK ILDDWGETCK
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产品特性
- This is a synthetic peptide designed for use in combination with anti-MANF Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) peptide
MANF 适用: 人, 犬, 小鼠, 大鼠 宿主: 合成 BP, Imm
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) peptideMANF 宿主: 合成 BP, WB, IHC
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
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背景
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MANF is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of MANF gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors, however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.
Alias Symbols: ARMET, ARP, MGC142148, MGC142150
Protein Size: 185 -
分子量
- 21 kDa
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基因ID
- 7873
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NCBI登录号
- NM_006010, NP_006001
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UniProt
- A8K878
抗原
-
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