Ligase IV, DNA, ATP-Dependent (LIG4) Peptide
LIG4
适用: 人
宿主: 合成
BP, IHC, WB
产品编号 ABIN979317
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Ligase IV, DNA, ATP-Dependent (LIG4) Peptide (ABIN979317)
抗原
LIG4
(Ligase IV, DNA, ATP-Dependent (LIG4))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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产品特性
- This is a synthetic peptide designed for use in combination with anti-LIG4 antibody (Catalog #: ARP34122_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))
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背景
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LIG4 encodes a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome.
Protein Interaction Partner: XRCC4,APLF,NHEJ1,PRKDC,SMC2,XRCC4,ATM,ATR,NHEJ1,PNKP,PRKDC,XRCC4
Protein Size: 911 -
分子量
- 104 kDa
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基因ID
- 3981
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NCBI登录号
- NM_002312, NP_002303
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UniProt
- Q8IY66
抗原
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