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Ligase IV, DNA, ATP-Dependent (LIG4) Peptide

LIG4 适用: 人 宿主: 合成 BP, IHC, WB
产品编号 ABIN979317
发货至: 中国
  • 抗原 See all LIG4 products
    LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))
    宿主
    资源
    • 3
    合成
    应用范围
    Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
    产品特性
    This is a synthetic peptide designed for use in combination with anti-LIG4 antibody (Catalog #: ARP34122_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    纯化方法
    Purified
  • 应用备注
    Each Investigator should determine their own optimal working dilution for specific applications.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    浓度
    1 mg/mL
    缓冲液
    Final peptide concentration is 1 mg/mL in PBS.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • 抗原
    LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))
    背景
    LIG4 encodes a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome.

    Protein Interaction Partner: XRCC4,APLF,NHEJ1,PRKDC,SMC2,XRCC4,ATM,ATR,NHEJ1,PNKP,PRKDC,XRCC4

    Protein Size: 911
    分子量
    104 kDa
    基因ID
    3981
    NCBI登录号
    NM_002312, NP_002303
    UniProt
    Q8IY66
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