Insulin-Like Growth Factor 1 Receptor (IGF1R) (Middle Region) Peptide
IGF1R
适用: 人
宿主: 合成
BP, IHC, WB
Quick Overview for Insulin-Like Growth Factor 1 Receptor (IGF1R) (Middle Region) Peptide (ABIN978431)
抗原
IGF1R
(Insulin-Like Growth Factor 1 Receptor (IGF1R))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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蛋白结构域
- Middle Region
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产品特性
- This is a synthetic peptide designed for use in combination with anti-IGF1R antibody (Catalog #: AVARP00004_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
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背景
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This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-140 DR007209.1 566-705 141-3559 X04434.1 136-3554 3560-4540 BC113610.1 3542-4522 4541-4921 DA486252.1 187-567 4922-5392 BX093045.1 248-718 5393-5768 CN414655.1 317-692 5769-6158 BM264223.1 185-574 6159-6580 BQ185364.1 187-608 6581-11242 AC069029.9 21278-25939 c
Alias Symbols: CD221, IGFIR, JTK13, MGC142170, MGC142172, MGC18216, IGFR
Protein Interaction Partner: CSK,EHD1,GNB2L1,GRB10,IRS1,IRS1,IRS2,ITGB1,JAK1,PIK3R2,PRKCD,PRKD1,SHC1,SOCS1,SOCS2,SOCS3,YWHAB,YWHAE,YWHAZ,ARHGEF12,CRK,CRKL,CSK,DOK4,DOK5,EHD1,ESR1,GIPC1,GNAI1,GNAI2,GNB2L1,GRB10,IGF1,IGF1R,IGF2,IGFBP3,INS,INSR,IRS1,IRS2,IRS4,ITGB1,JAK1,JAK2,KL,KRT27,MAP3K5,MDM2,NEDD4,PIK3R1,PIK3R2,PIK3R3,PRKCD,PRKD1,PTPN1,PTPN11,RASA1,SOCS1,SOCS2,SOCS3,SRC,STAT3,VAV3,WISP2,YWHAB,YWHAE,YWHAG,YWHAZ,ARHGEF12,CBL,CSK,EEA1,EGFR,EHD1,ESR1,GNAI1,GNB2L1,GRB10,IGF1,IGFBP3,IRS1,JAK1,MDM2,NEDD4,PIK3R3,PTK2,PTPN1,PTPN11,PXN,RASA1,SHC1,SNAP29,SOCS1,SOCS2,SOCS3,UBC,VAV3,YWHAB,YWHAE,YWHAG
Protein Size: 1367 -
分子量
- 71 kDa
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基因ID
- 3480
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NCBI登录号
- NM_000875, NP_000866
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UniProt
- P08069
抗原
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