Insulin-Degrading Enzyme (IDE) (N-Term) Peptide
IDE
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN978389
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
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Quick Overview for Insulin-Degrading Enzyme (IDE) (N-Term) Peptide (ABIN978389)
抗原
IDE
(Insulin-Degrading Enzyme (IDE))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- N-Term
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序列
- LDVHIGSLSD PPNIAGLSHF CEHMLFLGTK KYPKENEYSQ FLSEHAGSSN
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产品特性
- This is a synthetic peptide designed for use in combination with anti-IDE Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- IDE (Insulin-Degrading Enzyme (IDE))
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背景
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This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion.
Alias Symbols: FLJ35968, INSULYSIN
Protein Interaction Partner: APP,AR,IGF1,IGF2,INS,NR3C1,IGF1,IGF2,ZHX2
Protein Size: 1019 -
分子量
- 118 kDa
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基因ID
- 3416
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NCBI登录号
- NM_004969, NP_004960
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UniProt
- P14735
抗原
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