Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU) Peptide
HNRNPU
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all HNRNPU products
- HNRNPU (Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU))
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-HNRNPU antibody (Catalog #: ARP40519_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- HNRNPU (Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU))
- 别名
- AA408410 Peptide, AI256620 Peptide, AL024194 Peptide, AL024437 Peptide, AW557595 Peptide, C86794 Peptide, Hnrpu Peptide, SAFA Peptide, Sp120 Peptide, hnRNP U Peptide, SN1 Peptide, HNRPU Peptide, SAF-A Peptide, U21.1 Peptide, saf-a Peptide, heterogeneous nuclear ribonucleoprotein U Peptide, heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) S homeolog Peptide, heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) Peptide, Hnrnpu Peptide, HNRNPU Peptide, hnrnpu.S Peptide
- 背景
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HNRNPU belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. HNRNPU contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. But this cleavage does not affect the function of the encoded protein in RNA metabolism. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene.
Alias Symbols: HNRPU, SAF-A, U21.1, hnRNP U
Protein Interaction Partner: ACTB,CR2,ACTB,BTRC,CASP3,CD5,CR2,ELL,EP300,GRIN1,GRIN2D,GTF2H1,NDN,NDRG1,NR3C1,POU3F4,PRMT1,PTPN11,SFRS12,SMN2,STAU1,SYK,YAP1,ZNF689,CDK7,CDK9,EP300,GPN1,GTF2F1,HNRNPH1,NDN,NR3C1,POLR2A,POLR2J,POU3F4,PRMT1,RUVBL2,SFN
Protein Size: 806 - 分子量
- 89 kDa
- 基因ID
- 3192
- NCBI登录号
- NM_004501, NP_004492
- UniProt
- Q00839
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