Glucokinase (Hexokinase 4) (GCK) (N-Term) Peptide
GCK
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all GCK products
- GCK (Glucokinase (Hexokinase 4) (GCK))
- 蛋白结构域
- N-Term
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- RVMLVKVGEG EEGQWSVKTK HQMYSIPEDA MTGTAEMLFD YISECISDFL
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-GCK Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- GCK (Glucokinase (Hexokinase 4) (GCK))
- 背景
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Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Alias Symbols: FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, MODY2, LGLK
Protein Interaction Partner: GCKR,INS,PFKFB2,GCKR,MIG1,PFKFB2
Protein Size: 464 - 分子量
- 51 kDa
- 基因ID
- 2645
- NCBI登录号
- NM_033508, NP_277043
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