Flap Structure-Specific Endonuclease 1 (FEN1) (N-Term) Peptide
FEN1
适用: 人
宿主: 合成
BP, WB
Quick Overview for Flap Structure-Specific Endonuclease 1 (FEN1) (N-Term) Peptide (ABIN976808)
抗原
FEN1
(Flap Structure-Specific Endonuclease 1 (FEN1))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- N-Term
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序列
- APSAIRENDI KSYFGRKVAI DASMSIYQFL IAVRQGGDVL QNEEGETTSH
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产品特性
- This is a synthetic peptide designed for use in combination with anti-FEN1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))
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背景
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FEN1 removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
Alias Symbols: FEN-1, MF1, RAD2
Protein Interaction Partner: PCNA,PCNA,PCNA,APEX1,ARHGDIA,BLM,CDK1,CDK2,EEF1G,EP300,HNRNPA1,PCNA,RAD1,WRN,APEX1,ARHGDIA,BLM,CCNA2,CDK1,CDK2,DDX11,EEF1G,ENDOG,EP300,HNRNPA1,HUS1,NCAPG,PCNA,RAD1,RAD9A,WRN
Protein Size: 380 -
分子量
- 42 kDa
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基因ID
- 2237
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NCBI登录号
- NM_004111, NP_004102
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UniProt
- P39748
抗原
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