F-Box and WD Repeat Domain Containing 7 (FBXW7) (C-Term) Peptide
FBXW7
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN976771
发货至:
中国
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Contact Info
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中国
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Quick Overview for F-Box and WD Repeat Domain Containing 7 (FBXW7) (C-Term) Peptide (ABIN976771)
抗原
FBXW7
(F-Box and WD Repeat Domain Containing 7 (FBXW7))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- C-Term
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序列
- KTGEFIRNLV TLESGGSGGV VWRIRASNTK LVCAVGSRNG TEETKLLVLD
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产品特性
- This is a synthetic peptide designed for use in combination with anti-FBXW7 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
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背景
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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class, in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: FBXW7,FBW7, FBX30, SEL10,
Protein Size: 707 -
分子量
- 66 kDa
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基因ID
- 55294
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NCBI登录号
- NP_361014
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UniProt
- Q969H0
抗原
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