F-Box and WD Repeat Domain Containing 7 (FBXW7) (Middle Region) Peptide
FBXW7
适用: 小鼠
宿主: 合成
BP, WB, IHC
Quick Overview for F-Box and WD Repeat Domain Containing 7 (FBXW7) (Middle Region) Peptide (ABIN976770)
抗原
FBXW7
(F-Box and WD Repeat Domain Containing 7 (FBXW7))
宿主
小鼠
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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蛋白结构域
- Middle Region
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序列
- GIDEPLHIKR RKIIKPGFIH SPWKSAYIRQ HRIDTNWRRG ELKSPKVLKG
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产品特性
- This is a synthetic peptide designed for use in combination with anti-Fbxw7 Antibody(ARP37443_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
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背景
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Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Alias Symbols: 1110001A17Rik, AGO, Cdc4, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, SEL-10
Protein Interaction Partner: Jun,Npm1
Protein Size: 629 -
分子量
- 70 kDa
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基因ID
- 50754
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NCBI登录号
- NM_080428, NP_536353
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UniProt
- Q8VBV4
抗原
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