E2F Transcription Factor 2 (E2F2) (Middle Region) Peptide
E2F2
适用: 人
宿主: 合成
BP, WB, IHC
Quick Overview for E2F Transcription Factor 2 (E2F2) (Middle Region) Peptide (ABIN976079)
抗原
E2F2
(E2F Transcription Factor 2 (E2F2))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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蛋白结构域
- Middle Region
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产品特性
- This is a synthetic peptide designed for use in combination with anti-E2F2 antibody (Catalog #: ARP38418_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- E2F2 (E2F Transcription Factor 2 (E2F2))
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背景
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E2F2 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46 % amino acid identity to E2F1.The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46 % amino acid identity to E2F1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: E2F-2
Protein Interaction Partner: E2F4,RBL2,CDC25A,CDC6,E2F1,EAPP,FHL2,GAB2,JMY,MT1G,MYBL2,PPP1R13B,RB1,RB1,RB1,RBL1,RYBP,SETD8,TP53BP2,TP53INP1,UXT,ARID3A,BCAR1,BRD2,CDK3,RB1,RYBP,SETD8,SP1,TFDP1,TFDP2,YY1,BCAR1,BRD2,FHL2,RB1,RNF144A,RYBP,SETD8,SPIB,Sp1
Protein Size: 437 -
分子量
- 47 kDa
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基因ID
- 1870
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NCBI登录号
- NM_004091, NP_004082
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UniProt
- Q14209
抗原
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