Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1) (Middle Region) Peptide
DMTF1
适用: 人
宿主: 合成
BP, WB
Quick Overview for Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1) (Middle Region) Peptide (ABIN975884)
抗原
DMP1 (DMTF1)
(Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- Middle Region
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产品特性
- This is a synthetic peptide designed for use in combination with anti-DMTF1 antibody (Catalog #: ARP34828_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1) peptide
DMTF1 适用: 人 宿主: 合成 BP, Imm
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))
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背景
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DMTF1 is a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. DMTF1 is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of DMTF1 is regulated by binding of D-cyclins. The gene encoding DMTF1 is hemizygously deleted in approximately 40 % of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer.
Alias Symbols: DMP1, DMTF, FLJ41265, hDMP1
Protein Interaction Partner: ATF7IP,CCND1,CCND2,CCND3
Protein Size: 760 -
分子量
- 84 kDa
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基因ID
- 9988
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NCBI登录号
- NM_021145, NP_066968
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UniProt
- Q9Y222
抗原
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