DNA Methyltransferase 1-Associated Protein 1 (DMAP1) Peptide
DMAP1
适用: 人
宿主: 合成
BP, WB
Quick Overview for DNA Methyltransferase 1-Associated Protein 1 (DMAP1) Peptide (ABIN975860)
抗原
DMAP1
(DNA Methyltransferase 1-Associated Protein 1 (DMAP1))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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产品特性
- This is a synthetic peptide designed for use in combination with anti-DMAP1 antibody (Catalog #: ARP39381_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))
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背景
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DMAP1 is a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.
Alias Symbols: EAF2, SWC4, MEAF2, DNMAP1, DNMTAP1
Protein Interaction Partner: DNMT1,RGS6,C19orf2,C20orf20,DAXX,DNMT1,HDAC2,ING1,RGS6,TOMM34,TSG101,C19orf2,DNMT1,ING1,ING3,RGS6,RUVBL1,RUVBL2,TSG101
Protein Size: 467 -
分子量
- 53 kDa
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基因ID
- 55929
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NCBI登录号
- NM_019100, NP_061973
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UniProt
- Q9NPF5
抗原
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