DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) Peptide
DFFA
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all DFFA products
- DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-DFFA antibody (Catalog #: ARP30359_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))
- 别名
- DFF-45 Peptide, DFF1 Peptide, ICAD Peptide, A330085O09Rik Peptide, DFF35 Peptide, Dff45 Peptide, ICAD-L Peptide, ICAD-S Peptide, DFFA Peptide, zgc:92229 Peptide, DNA fragmentation factor subunit alpha Peptide, DNA fragmentation factor, alpha subunit Peptide, DNA fragmentation factor, 45kDa, alpha polypeptide Peptide, DNA fragmentation factor, alpha polypeptide Peptide, DFFA Peptide, Dffa Peptide, dffa Peptide
- 背景
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Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alias Symbols: DFF-45, DFF1, Ion ChannelAD, ICAD
Protein Interaction Partner: CASP3,CASP7,CIDEB,DFFB,EWSR1,GZMB,NECAB2,STRN4,YWHAG,YWHAZ,BAK1,CIDEB,DFFB,EWSR1,HERC1,MCC,NAP1L5,NECAB2,TMBIM4,USP15,YWHAZ
Protein Size: 331 - 分子量
- 37 kDa
- 基因ID
- 1676
- NCBI登录号
- NM_004401, NP_004392
- UniProt
- O00273
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