Cochlin (COCH) (N-Term) Peptide
COCH
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all COCH products
- COCH (Cochlin (COCH))
- 蛋白结构域
- N-Term
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- AHPPTGKRLK KTPEKKTGNK DCKADIAFLI DGSFNIGQRR FNLQKNFVGK
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-COCH Antibody(ARP59585_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- COCH (Cochlin (COCH))
- 别名
- AW122937 Peptide, Coch-5B2 Peptide, D12H14S564E Peptide, COCH-5B2 Peptide, COCH5B2 Peptide, DFNA9 Peptide, cochlin Peptide, Coch Peptide, COCH Peptide
- 背景
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The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94 % and 79 % amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.
Alias Symbols: COCH-5B2, COCH5B2, DFNA9
Protein Size: 550 - 分子量
- 57 kDa
- 基因ID
- 1690
- NCBI登录号
- NM_001135058, NP_001128530
- UniProt
- O43405
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