Calsyntenin 1 (CLSTN1) (N-Term) Peptide
CLSTN1
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN975094
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Quick Overview for Calsyntenin 1 (CLSTN1) (N-Term) Peptide (ABIN975094)
抗原
Calsyntenin 1 (CLSTN1)
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- N-Term
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序列
- KPWLEPTYHG IVTENDNTVL LDPPLIALDK DAPLRFAESF EVTVTKEGEI
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产品特性
- This is a synthetic peptide designed for use in combination with anti-CLSTN1 Antibody(ARP44580_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Calsyntenin 1 (CLSTN1)
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背景
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CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment,CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
Alias Symbols: CSTN1, FLJ32258, KIAA0911, PIK3CD, XB31alpha, alcalpha1, alcalpha2, CDHR12, ALC-ALPHA
Protein Interaction Partner: APBA2,APBB1,BAHCC1,CLSTN1,COL17A1,KIF2A,KLC1,KLC2,MCM3AP,PRNP,SETDB1,SLK,TOPBP1,TRIP12,APBA2,APP,PSEN1
Protein Size: 981 -
分子量
- 110 kDa
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基因ID
- 22883
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NCBI登录号
- NM_001009566, NP_001009566
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UniProt
- O94985
抗原
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