Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2) Peptide
CHRNB2
适用: 人
宿主: 合成
BP, WB
Quick Overview for Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2) Peptide (ABIN974960)
抗原
CHRNB2
(Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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产品特性
- This is a synthetic peptide designed for use in combination with anti-CHRNB2 antibody (Catalog #: ARP37669_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2) peptide
CHRNB2 适用: 人, Cow, 犬, 小鼠, Pig, 大鼠 宿主: 合成 BP, Imm
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CHRNB2 (Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2))
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背景
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Mutations in nAChRs are found in a rare form of nocturnal frontal lobe epilepsy . Previously, some nAChR mutations have been described that are associated with additional neurological features such as psychiatric disorders or cognitive defects. A new CHRNB2 mutation located in transmembrane region 3 (M3), outside the known ADNFLE mutation cluster. The CHRNB2 mutation I312M, which occurred de novo in twins, markedly increases the receptor's sensitivity to acetylcholine. Phenotypically, the mutation is associated not only with typical ADNFLE, but also with distinct deficits in memory. The cognitive problems are most obvious in tasks requiring the organization and storage of verbal information.
Alias Symbols: EFNL3, nAChRB2
Protein Interaction Partner: CHRNA4,CHRNA2,CHRNA4,CRELD2
Protein Size: 502 -
分子量
- 57 kDa
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基因ID
- 1141
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NCBI登录号
- NM_000748, NP_000739
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UniProt
- P17787
抗原
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