CD209 (CD209) (N-Term) Peptide
CD209
适用: 人
宿主: 合成
BP, WB
Quick Overview for CD209 (CD209) (N-Term) Peptide (ABIN974654)
抗原
DC-SIGN/CD209 (CD209)
(CD209)
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- N-Term
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序列
- AGCLGHGPLV LQLLSFTLLA GLLVQVSKVP SSISQEQSRQ DAIYQNLTQL
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产品特性
- This is a synthetic peptide designed for use in combination with anti-CD209 Antibody(ARP42586_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- DC-SIGN/CD209 (CD209) (CD209)
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背景
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This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332, often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
Alias Symbols: CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, MGC129965
Protein Interaction Partner: SP1,HCVgp1,CD209,CEACAM1,CLEC4M,ICAM2,ICAM3,ITGAM,CD209,CLEC4M
Protein Size: 404 -
分子量
- 46 kDa
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基因ID
- 30835
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NCBI登录号
- NM_021155, NP_066978
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UniProt
- Q9NNX6
抗原
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