BCL2-Associated Athanogene 4 (BAG4) (C-Term) Peptide
BAG4
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN973715
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Quick Overview for BCL2-Associated Athanogene 4 (BAG4) (C-Term) Peptide (ABIN973715)
抗原
BAG4
(BCL2-Associated Athanogene 4 (BAG4))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- C-Term
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序列
- EVEEFVGKKT DKAYWLLEEM LTKELLELDS VETGGQDSVR QARKEAVCKI
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产品特性
- This is a synthetic peptide designed for use in combination with anti-BAG4 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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BCL2-Associated Athanogene 4 (BAG4) peptide
BAG4 适用: 人 宿主: 合成 BP, Imm
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- BAG4 (BCL2-Associated Athanogene 4 (BAG4))
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背景
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The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Alias Symbols: BAG-4, SODD
Protein Interaction Partner: BCL2,APOBEC1,BCL2,HSPA1A,TNFRSF1A,TNFRSF25,APOBEC1,HSP90AA1,HSPA4,HSPA8,TNFRSF1A,TNFRSF25
Protein Size: 457 -
分子量
- 50 kDa
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基因ID
- 9530
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NCBI登录号
- NM_004874, NP_004865
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UniProt
- O95429
抗原
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