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BCL2-Associated Athanogene 3 (BAG3) (Middle Region) Peptide

BAG3 适用: 人 宿主: 合成 BP, WB
产品编号 ABIN973713
发货至: 中国
  • 抗原 See all BAG3 products
    BAG3 (BCL2-Associated Athanogene 3 (BAG3))
    蛋白结构域
    Middle Region
    宿主
    资源
    • 7
    合成
    应用范围
    Blocking Peptide (BP), Western Blotting (WB)
    产品特性
    This is a synthetic peptide designed for use in combination with anti-BAG3 antibody (Catalog #: ARP48251_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    纯化方法
    Purified
  • 应用备注
    Each Investigator should determine their own optimal working dilution for specific applications.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    浓度
    1 mg/mL
    缓冲液
    Final peptide concentration is 1 mg/mL in PBS.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • 抗原
    BAG3 (BCL2-Associated Athanogene 3 (BAG3))
    背景
    BAG3 inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. BAG3 has anti-apoptotic activity.BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

    Alias Symbols: BAG-3, BIS, CAIR-1, MGC104307

    Protein Interaction Partner: BCL2,BCL2,DAZAP2,DVL2,FAM189A2,HSPA1A,HSPA8,HSPB8,PLCG1,AMOT,DAZAP2,DVL2,FAM189A2,HSPA1A,HSPA8,HSPB8,PLCG1

    Protein Size: 575
    分子量
    61 kDa
    基因ID
    9531
    NCBI登录号
    NM_004281, NP_004272
    UniProt
    O95817
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