Androgen Receptor (AR) (N-Term) Peptide
AR
适用: 人
宿主: 合成
BP, WB
Quick Overview for Androgen Receptor (AR) (N-Term) Peptide (ABIN973356)
抗原
Androgen Receptor (AR)
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- N-Term
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产品特性
- This is a synthetic peptide designed for use in combination with anti-AR antibody (Catalog #: ARP30974_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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Androgen Receptor (AR) peptide
AR 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig 宿主: 合成 BP, Imm
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Androgen Receptor (AR)
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背景
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AR has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS).The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
Alias Symbols: AIS, DHTR, HUMARA, KD, NR3C4, SBMA, SMAX1, TFM, HYSP1
Protein Interaction Partner: AKT1,CASP1,CASP3,CASP7,CASP8,CAV1,FGF8,KLK2,KLK3,NCOA1,NCOA1,NCOA2,RB1,TGFB1I1,AES,AHR,AKT1,APOL2,APPBP2,AR,ATF2,BAG1,BRCA1,CALM1,CALR,CASP1,CASP3,CASP7,CASP8,CAV1,CCND1,CCNE1,CCNH,CDC25A,CDC25B,CDC37,CDK1,CDK6,CDK7,CDK9,COX5B,CREBBP,CTDSP2,CTNNB1,CUL4B,DAP3,DAXX,DCAF6,DDC,EFCAB6,EGFR,EP300,ESR1,ETV5,FHL2,FLNA,FOXA1,FOXO1,GAK,GAPDH,GNB2L1,GRIP1,GSK3B,GSN,GTF2F1,GTF2F2,GTF2H1,HDAC1,HIF1A,HIPK3,HMGB1,HSP90AA1,IARS,IDE,IFI16,IL6ST,JMJD1C,JUN,KAT2B,KAT5,KDM1A,KIF1A,KLK2,MAPK1,MDM2,MED1,MED14,MYBBP1A,MYST2,NCOA1,NCOA2,NCOA3,NCOA4,NCOR1,NCOR2,NFKB1,NISCH,NONO,NR0B1,NR0B2,NR2C1,NR2C2,NR3C1,NR3C2,NR5A1,NRIP1,NSD1,PA2G4,PAK6,PIAS1,PIAS2,PIAS3,PIAS4,PNRC1,PNRC2,POU2F1,POU5F1,PRMT1,PSMC3IP,PTEN,PXN,RAC3,RAD54L2,RAD9A,RAF1,RAN,RANBP9,RB1,RBAK,RCHY1,RELA,RNASEL,RNF14,RNF4,RUNX1,RUNX2,SART3,SLC25A4,SMAD1,SMAD3,SMAD4,SP1,SPDEF,SRC,SRY,STAT3,STUB1,SUMO1,SVIL,TCF4,TGFB1I1,TGIF1,TMF1,TRIM24,TRIP4,TSG101,UBE2I,UBE3A,UXT,WIPI1,XRCC5,XRCC6,ZMIZ1,AES,AKT1,AR,BAG1,BRCA1,CALM1,CALR,CAV1,CCND1,CCNE1,CCNH,CDC25B,CDC37,CDK7,CDK9,CEBPA,CEBPB,COX5B,CREBBP,CTNNB1,DAP3,DAXX,DCC,EFCAB6,EGFR,ETV5,FHL2,FLNA,FOXA1,FOXO1,GAPDH,GNB2L1,GRIP1,GSK3A,GSK3B,GSN,GTF2F1,GTF2F2,GTF2H1,HDAC1,HDAC3,HDAC4,HMGB1,HMGB2,HNF4A,HSP90AA1,HSPA1A,HSPB2,IL6ST,JUN,KAT5,MAGEA11,MAPK1,MDM2,MED1,MYST2,NCOA1,NCOA2,NCOA3,NCOA4,NCOA6,NCOR1,NCOR2,NONO,NR0B1,NR0B2,NR2C1,NR2C2,NSD1,PA2G4,PAK6,PATZ1,PELP1,PIAS1,PIAS2,PIAS3,PIAS4,PMEPA1,POU2F1,POU2F2,PRKDC,PRMT1,PRPF6,PSPC1,PTEN,RAD9A,RAF1,RAN,RANBP9,RB1,RCHY1,RNF14,RNF4,SART3,SELENBP1,SMAD3,SMAD4,SMARCA4,SMARCC1,SP1,SPDEF,SRC,SRY,STAT3,SVIL,TBP,TCF4,TDG,TGFB1I1,TMF1,TP53,TRIM24,TRIM68,TSG101,UBC,UBE2I,UXT,XRCC5,XRCC6,YWHAQ,ZMIZ1
Protein Size: 920 -
分子量
- 99 kDa
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基因ID
- 367
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NCBI登录号
- NM_000044, NP_000035
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UniProt
- P10275
抗原
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