Apolipoprotein E (APOE) Peptide
APOE
适用: 人
宿主: 合成
BP, IHC, WB
产品编号 ABIN973323
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Quick Overview for Apolipoprotein E (APOE) Peptide (ABIN973323)
抗原
APOE
(Apolipoprotein E (APOE))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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产品特性
- This is a synthetic peptide designed for use in combination with anti-APOE antibody (Catalog #: ARP54283_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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Apolipoprotein E (APOE) peptide
APOE 适用: 人 宿主: 合成 BP, Imm
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- APOE (Apolipoprotein E (APOE))
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背景
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Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AD2, MGC1571, apoprotein, LPG, LDLCQ5
Protein Interaction Partner: CNTF,CNTF,HCVgp1,A2M,ALB,APOE,APP,CNTF,CTSB,LDLR,LRP1,LRP2,LRP8,MAP2,MAPT,NEFM,PLTP,PRNP,SCARB1,VLDLR,A2M,LRP2,LRP8,MAPT,NEFM,PLTP
Protein Size: 317 -
分子量
- 34 kDa
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基因ID
- 348
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NCBI登录号
- NM_000041, NP_000032
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UniProt
- P02649
抗原
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