Ankyrin 1, Erythrocytic (ANK1) Peptide
ANK1
适用: 人
宿主: 合成
BP, WB, IHC
产品编号 ABIN973205
发货至:
中国
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Contact Info
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中国
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北京 101111
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Quick Overview for Ankyrin 1, Erythrocytic (ANK1) Peptide (ABIN973205)
抗原
Erythrocyte Ankyrin (ANK1)
(Ankyrin 1, Erythrocytic (ANK1))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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产品特性
- This is a synthetic peptide designed for use in combination with anti-ANK1 antibody (Catalog #: ARP42566_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Erythrocyte Ankyrin (ANK1) (Ankyrin 1, Erythrocytic (ANK1))
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背景
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Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described, however, the precise functions of the various isoforms are not known.Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats, a central region with a highly conserved spectrin binding domain, and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described, however, the precise functions of the various isoforms are not known. Alternative polyadenylation accounting for the different sized erythrocytic ankyrin 1 mRNAs, has also been reported. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.
Alias Symbols: ANK, SPH1, SPH2
Protein Interaction Partner: CD44,EPB42,ITPR3,L1CAM,NBPF3,NFASC,OBSCN,PLDN,RHAG,SLC4A1,SLC4A3,SPTAN1,TIAM1,TTN,L1CAM,OBSCN,RHAG,SLC4A1,SLC4A3,SPTA1,SPTB,TIAM1,TTN
Protein Size: 155 -
分子量
- 17 kDa
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基因ID
- 286
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NCBI登录号
- NM_020478, NP_065211
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UniProt
- Q53ER1
抗原
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