Actinin, alpha 2 (ACTN2) Peptide
ACTN2
适用: 人
宿主: 合成
BP, WB, IHC
产品编号 ABIN972867
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Actinin, alpha 2 (ACTN2) Peptide (ABIN972867)
抗原
ACTN2
(Actinin, alpha 2 (ACTN2))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
-
-
产品特性
- This is a synthetic peptide designed for use in combination with anti-ACTN2 antibody (Catalog #: ARP41463_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
纯化方法
- Purified
-
-
-
-
应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
浓度
- 1 mg/mL
-
缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
-
注意事项
- Avoid repeated freeze-thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- ACTN2 (Actinin, alpha 2 (ACTN2))
-
背景
-
The alpha-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin (ACTN2 and ACTN3) are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibres, while ACTN3 expression is restricted to a subset of type 2 fibres. Murine Actn2 and Actn3 are differentially expressed, spatially and temporally, during embryonic development and, in contrast to humans, alpha-actinin-2 expression does not completely overlap alpha-actinin-3 in postnatal skeletal muscle, suggesting independent function.Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Transcript variants resulting from the use of multiple poly_A sites have been observed.
Alias Symbols: CMD1AA
Protein Interaction Partner: ANG,CAPN1,DISC1,GRIN1,LDB3,MYOZ1,ACTN2,ACTN3,ADAM12,ADORA2A,ANG,ATXN2,CAMK2A,CAMK2D,CAMK2G,CAPN1,COIL,DISC1,DLG1,DLG4,EPS8L1,GRIN1,GRIN2B,KAT2B,KCNA4,KCNA5,LDB3,LRP12,LRRC7,MED14,MYOZ1,MYOZ2,MYOZ3,MYPN,NCOA2,NCOR1,NR1I2,NRIP1,PALLD,PDLIM1,PKD2,RAVER1,SELE,SNW1,SSX2IP,TTN,UTRN,ACTN3,ADAM12,DISC1,DLG1,DLG4,GRIN2B,KCNA5,LDB3,MYOZ1,MYPN,PDLIM1,ST7,TNN,Tuba1a
Protein Size: 894 -
分子量
- 98 kDa
-
基因ID
- 88
-
NCBI登录号
- NM_001103, NP_001094
-
UniProt
- P35609
抗原
-
You are here:
