IkB Peptide
Rockland 100-4186p
宿主: 合成
Sodium azide
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- 抗原
- IkB
- 蛋白类型
- Synthetic
- 资源
- 合成
- Supplier Product No.
- 100-4186p
- Supplier
- Rockland
- 原理
- IKBß Peptide
- 产品特性
- NF-kappa-B inhibitor beta peptide, NF-kappa-BIB, I-kappa-B-beta, Thyroid receptor-interacting protein 9, TRIP-9, IkB-B, control peptide, blocking peptide
- 纯度
- Greater than 95% specific peptide
- 过滤
- Sterile filtered
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- 应用备注
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Application Note: Control peptide should be used at 1.0 μg per 1.0 μL of antiserum in per assay.
Other: Control peptide should be used at 1.0 μg per 1.0 μL of antiserum per assay.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1.0 mg/mL
- 缓冲液
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Buffer: None
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide - 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
- 有效期
- 6 months
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- 抗原
- IkB
- 背景
- Background: Control peptide for use in control assays with purified antibody Anti-IKBB (p/n 100-4186). NFkB was originally identified as a factor that binds to the immunoglobulin kappa light chain enhancer in B cells. It was subsequently found in non-B cells in an inactive cytoplasmic form consisting of NFkB bound to IkB. NFkB was originally identified as a heterodimeric DNA binding protein complex consisting of p65 (RelA) and p50 (NFKB1) subunits. Other identified subunits include p52 (NFKB2), c-Rel, and RelB. The p65, cRel, and RelB subunits are responsible for transactivation. The p50 and p52 subunits possess DNA binding activity but limited ability to transactivate. p52 has been reported to form transcriptionally active heterodimers with the NFkB subunit p65, similar to p50/p65 heterodimers. The heterodimers of p52/p65 and p50/p65 are regulated by physical inactivation in the cytoplasm by IkB-a. IkB-a binds to the p65 subunit, preventing nuclear localization and DNA binding. Low levels of p52 and p50 homodimers can also exist in cells.
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