A synthetic peptide for use as a blocking control in assays to test for specificity of CRISP1 antibody, Alternative Names: CRISP1 control peptide, CRISP1 antibody Blocking Peptide, Anti-CRISP1 Blocking Peptide, Cysteine-Rich Secretory Protein 1 Blocking Peptide, AEGL1 Blocking Peptide, ARP Blocking Peptide, CRISP-1 Blocking Peptide, HSCRISP1D Blocking Peptide, HSCRISP1G Blocking Peptide, HUMARP Blocking Peptide
Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. CRISP1 is a member of the cysteine-rich secretory protein (CRISP) family. It is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head where it plays a role at fertilization in sperm-egg fusion through complementary sites localized on the egg surface.