A synthetic peptide for use as a blocking control in assays to test for specificity of SEPP1 antibody, Alternative Names: SEPP1 control peptide, SEPP1 antibody Blocking Peptide, Anti-SEPP1 Blocking Peptide, Selenoprotein P Plasma 1 Blocking Peptide, SELP Blocking Peptide, SeP Blocking Peptide, SEPP1, SEPP-1, SEPP 1, SEPP-1 Blocking Peptide, SEPP 1 Blocking Peptide
SEPP1 is a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space.