Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) Peptide
MAP2K2
适用: 哺乳动物
宿主: 合成
BP, WB, IHC
Quick Overview for Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) Peptide (ABIN940180)
抗原
MEK2 (MAP2K2)
(Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2))
宿主
哺乳动物
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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蛋白类型
- Synthetic
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序列
- LARRKPVLPA LTINPTIAEG PSPTSEGASE ANLVDLQKKL EELELDEQQK
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产品特性
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A synthetic peptide for use as a blocking control in assays to test for specificity of MAP2 K2 antibody,
Alternative Names: MAP2K2 control peptide, MAP2K2 antibody Blocking Peptide, Anti-MAP2K2 Blocking Peptide, Mitogen-Activated Protein Kinase 2 Blocking Peptide, MAPKK2 Blocking Peptide, MEK2 Blocking Peptide, MKK2 Blocking Peptide, PRKMK2 Blocking Peptide, MAP2, MAP-2, MAP 2, MAP-2 Blocking Peptide, MAP 2 Blocking Peptide
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应用备注
- Optimal conditions should be determined by the investigator
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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缓冲液
- PBS
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C long term.
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- MEK2 (MAP2K2) (Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2))
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背景
- MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in MAP2K2 gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
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分子量
- 44 kDa
抗原
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